Here's my guide to the perfect 10 day road trip from Milan to Rome, a popular tourist route. It's only a 6 hour drive from Milan to Rome. But this well-traveled route is dense with amazing must see medieval villages, ornate palazzos, Roman ruins, and sublime treasures of the Renaissance.

There's plenty of great destinations to explore along the way. This super detailed itinerary is perfectly adjustable. You can make it shorter or longer, depending on your available vacation time or personal fast/slow pace. I've tried to give you a balance of cities and leisurely villages, with day trip options as well.