Andrea Crisanti was on a 30-hour flight from Italy to Australia for a conference on 22 February when some disturbing news appeared on his phone. Italy had just had its first COVID-19 death, and more cases were accumulating fast. He asked conference organizers to move his talk to the first day, and made the grueling trip back home after that. “It’s something I do not recommend,” he says.

Crisanti, head of the microbiology department at the University of Padua, already knew trouble was coming and had geared up his lab to do large-scale testing for the new coronavirus. As it began to devastate his nation, Crisanti put his university and region at the forefront of the fight with an all-out campaign of testing and quarantine, even when that meant defying conventional wisdom.