Spello is a municipality in Italy’s central region of Umbria with roots in antiquity. Located about 10 kilometers (6 mi) from Assisi, on the opposite side of Mt. Subasio, like Assisi, it was inhabited by ancient Umbri until Roman occupation in the 1st century BC. Like the rest of the region, it was evangelized largely from the 2nd through 4th centuries.

Though overshadowed by the nearby city of Sts. Francis and Clare, Spello is worth a visit for its striking churches and artwork. The church of Santa Maria Maggiore boasts the Baglioni chapel with frescoes by Perugino and Pinturicchio from the high Renaissance. The church of Sant’Andrea (St. Andrew) also has a work by Pinturicchio – a wooden panel depicting the Virgin with Child.